2024
Buchholz S, MA Al Kabbani, M Bell-Simons, L Kluge, C Cakmak, J Klimek, N Haag, LC Iohan, A Coulon, MR Costa, D Kilinc and H Zempel.
The TAU isoform 1N4R confers vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta and phosphorylated TAU-induced neuronal dysfunction. Alzheimers Dement (accepted)
Ropert B, S Bannwarth, EC Genin, L Vaillant-Beuchot, S Lacas-Gervais, B Madji Hounoum, A Bernardin, NK Dinh, A Mauri-Crouzet, MA D’Elia, G Augé, F Lespinasse, A Di Giorgio, W Meira, N Bonnefoy, L Monassier,
M Schiff, L Sago, D Kilinc, F Brau, V Redeker, D Bohl, D Tribouillard-Tanvier, V Procaccio, S Azoulay, JE Ricci, A Delahodde and V Paquis-Flucklinger.
Nifuroxazide rescues the deleterious effects due to CHCHD10-associated MICOS defects in disease models. Brain awae348
Ellis C, NL Ward, M Rice, NJ Ball, P Walle, C Najdek, D Kilinc, JC Lambert, J Chapuis and BT Goult. The structure of an
Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer’s Disease. Open Biol 14:240185
Coulon A, F Rabiller, M Takalo, A Roy, H Martiskainen, D Siedlecki-Wullich, T Mendes, C Lemeu, L Iohan Carvalho, A Ehrardt, AR Melo de Ferias, M Hulsman, C Najdek,
N Lannette-Weimann, A Freire-Regatillo, P Amouyel, C Charbonnier, O Dols-Icardo, H Jeskanen, T Kuulasmaa, M Kurki, J Hardy, M Wagner, S Heikkinen, H Holstege, P Makinen, G Nicolas, S Mead, A Ramirez, T Rauramaa, A Palotie, R Sims, H Soininen,
J van Swieten, J Williams, RM Willman, C Bellenguez, B Grenier-Boley, C Gelle, E Lambert, AM Ayral, F Demiautte, MR Costa, S Deforges, D Kilinc, C Mulle, J Chapuis, M Hiltunen, J Dumont and JC Lambert.
Neuronal downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease hallmarks. bioRxiv 2024.04.29.591575
Gomez-Murcia V, A Launay, K Carvalho, A Burgard, C Meriaux, R Caillierez, S Eddarkaoui, D Kilinc,
D Siedlecki, M Besegher, S Bégard, B Thiroux, M Jung, O Nebie, M Wisztorski, N Déglon, C Montmasson, AP Bemelmans, M Hamdane, T Lebouvier, D Vieau, I Fournier, L Buee, S Lévi, LV Lopes, AL Boutillier, E Faivre and D Blum.
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice. Brain 147:2691
Saha O, AR Melo de Farias, A Pelletier, D Siedlecki-Wullich, B Soares Landeira, J Gadaut, A Carrier, AC Vreulx, K Guyot, Y Shen, A Bonnefond,
P Amouyel, J TCW, D Kilinc, CM Queiroz, F Delahaye, JC Lambert and MR Costa. The Alzheimer’s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons.
Mol Psychiatry 29:2634
Lefebvre C, AC Vreulx, C Dumortier, S Bégard, C Gelle, D Siedlecki-Wullich, M Colin, D Kilinc* and S Halliez*. Integration of microfluidic devices with microelectrode arrays to functionally assay amyloid-β-induced synaptotoxicity. ACS Biomater Sci Eng 10:1856 (* co-corresponding authors)
2023
Coulon A, D Siedlecki-Wullich, C Najdek, C Gelle, AM Ayral, F Demiautte, E Lambert, A Vandeputte, P Brodin, T Mendes, JC Lambert, D Kilinc, J Dumont and J Chapuis. High-content screening of synaptic density modulators in primary neuronal cultures. Curr Protoc 3:e904
2021
Blasiak A*, D Kilinc* and JM Peyrin*. Subcellular compartmentalization for neurobiology: Focusing on the axon, in "Handbook of Neuroengineering" (NV Thakor, ed), Springer. DOI: 10.1007/978-981-15-2848-4_1-1 (* co-corresponding)
Eysert
F, A Coulon, E Boscher, AC Vreulx, A Flaig, T Mendes, S Hughes, B
Grenier-Boley, X Hanoulle, F Demiautte, M Marttinen, M Takalo, P Amouyel, S
Desai, I Pike, M Hiltunen, F Chécler, M Farinelli, C Delay, N Malmanche, SS
Hébert, J Dumont, D Kilinc, JC Lambert and J Chapuis. Alzheimer's genetic risk factor FERMT2
(Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner. Mol Psychiatry
26:5592
2020
Kilinc D*, AC Vreulx, T Mendes, A Flaig, D Marques-Coelho, M Verschoore, F Demiautte, P Amouyel, Neuro-CEB Brain Bank, F Eysert, P Dourlen, J Chapuis, MR Costa, N Malmanche, F Checler and JC Lambert*. Pyk2 overexpression in postsynaptic neurons blocks amyloid β1-42-induced synaptotoxicity in a microfluidic co-culture model. Brain Commun 2:fcaa139 (* co-corresponding authors)
Mendes T, A Herledan, F Leroux, B Deprez, JC Lambert and D Kilinc. High-content screening for protein-protein interaction modulators using proximity ligation assay in primary neurons. Curr Protoc Cell Biol 86:e100
2019
Sartori M, T Mendes, S Desai, A Lasorsa, A Herledan, N Malmanche, P Mäkinen, M Marttinen, I Malki, J Chapuis, A Flaig, AC Vreulx, M Ciancia, P Amouyel, F Leroux, B Déprez, FX Cantrelle, D Maréchal, L Pradier, M Hiltunen, I Landrieu, D Kilinc*, Y Herault*, J Laporte* and JC Lambert*. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. Acta Neuropathol 138:631 (* co-last authors)
Dourlen P, D Kilinc, N Malmanche, J Chapuis and JC Lambert. The new genetic landscape of Alzheimer’s disease: from amyloid cascade to genetically driven synaptic failure hypothesis? Acta Neuropathol 138:221
2018
Kilinc D. The emerging role of mechanics in synapse formation and plasticity. Front Cell Neurosci 12:483
Lesniak A*, D Kilinc*, A Blasiak, G Galea, JC Simpson and GU Lee. Dynein-mediated axonal retrograde transport of nanoparticles in primary neurons depends on particle charge and lysosomal avoidance. Small 1803758 (* co-first authors)
2017
Kilinc D*, A Blasiak, MA Baghban, NC Carville, A Al-Adli, RM Al-Shammari, JH Rice, GU Lee*, K Gallo* and BJ Rodriguez*. Charge and topography patterned lithium niobate provides physical cues to fluidically isolated cortical axons. Appl Phys Lett 110:053702 (* co-corresponding authors)
Blasiak A, D Kilinc* and GU Lee*. Neuronal cell bodies remotely regulate axonal growth response to localized Netrin-1 treatment via second messenger and DCC dynamics. Front Cell Neurosci 10:298 (* co-corresponding authors)
2016
Kilinc D, CL Dennis and GU Lee. Bio-nano-materials for localized mechanochemical stimulation of cell growth and death. Adv Mater 28:5672
Kilinc D, J Schwab, S Rampini, OW Ikpekha, A Thampi, A Blasiak, P Li, R Schwamborn, W Kolch, D Matallanas and GU Lee. A microfluidic dual gradient generator for conducting cell-based drug combination assays. Integr Biol 8:39 (selected as "hot paper" by the reviewers)
2015
Blasiak A, GU Lee* and D Kilinc*. Neuron sub-populations with different elongation rates and DCC dynamics exhibit distinct responses to isolated netrin-1 treatment. ACS Neuro 6:1578 (cover article; * co-corresponding authors)
Kilinc D, A Blasiak and GU Lee. Microtechnologies for studying the role of mechanics in axon growth and guidance. Front Cell Neurosci 9:282
Rampini S, D Kilinc, P Li, C Monteil, D Gandhi and GU Lee. Micromagnet arrays for on-chip focusing, switching, and separation of superparamagnetic beads and single cells. Lab Chip 15:3370
Kilinc D*, Lesniak A*, SA Rashdan, D Gandhi, A Blasiak, PC Fannin, A von Kriegsheim, W Kolch and GU Lee. Mechanochemical stimulation of MCF7 cells with rod-shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of ERK. Adv Healthc Mater 4:395-404. (* co-first authors)
2014
Kilinc D, A Blasiak, JJ O'Mahony and GU Lee. Low piconewton towing of CNS axons against diffusing and surface-bound repellents requires the inhibition of motor protein-associated pathways. Sci Rep 4:7128
Lee GU, K Ivanov, D Kilinc, E Martines, A Blasiak, P Li and MJ Higgins. Characterization of intermolecular and intramolecular interactions with the atomic force microscope, in "Handbook of Imaging in Biological Mechanics" (CP Neu and GM Genin, eds), CRC Press, 445–456.
Lesniak A*, Kilinc D*, SA Rashdan, A von Kriegsheim, B Ashall, D Zerulla, W Kolch and GU Lee. In vitro study of the interaction of heregulin functionalized magnetic-optical nanorods with MCF7 and MDA-MB-231 cells. Faraday Discuss 175:189-201. (* co-first authors)
Kilinc D and GU Lee. Advances in magnetic tweezers for single molecule and cell biophysics. Integr Biol 6:27-34. (top ten most accessed Integr Biol articles in 2014 Q1; selected as "hot paper" by the reviewers)
2013
Stoeckli ET, D Kilinc, B Kunz, S Kunz, GU Lee, E Martines, C Rader and D Suter. Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules. Curr Protoc Cell Biol 61:9.5.1-9.5.85.
Magnifico S, Saias L, Deleglise B, Duplus E, D Kilinc, Miquel MC, Viovy JL, Brugg B and Peyrin JM. NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration. FASEB J 27:4712-4722.
Li P, D Kilinc, YF Ran and GU Lee. Flow enhanced non-linear magnetophoretic separation of beads based on magnetic susceptibility. Lab Chip 13:4400-4408.
O'Mahony JJ, M Platt, D Kilinc and GU Lee. Synthesis of superparamagnetic particles with tunable morphologies: the role of nanoparticle-nanoparticle interactions. Langmuir 29:2546-2553.
2012
Kilinc D, A Blasiak, JJ O'Mahony, DM Suter and GU Lee. Magnetic tweezers-based force clamp reveals mechanically distinct apCAM domain interactions. Biophys J 103:1120-1129.
2011
Kilinc D, JM Peyrin, V Soubeyre, S Magnifico, L Saias, JL Viovy and B Brugg. Wallerian-like degeneration of central neurons after synchronized and geometrically registered mass axotomy in a three-compartmental microfluidic chip. Neurotox Res 19:149-161.
2009
Kilinc D, G Gallo and KA Barbee. Mechanical membrane injury induces axonal beading through localized activation of calpain. Exp Neurol 219:553-561.
Kilinc D, G Gallo and KA Barbee. An interactive image processing and analysis algorithm for the quantification of axonal beading. Comput Meth Prog Bio 95:62-71.
2008
Peyrin JM, L Saias, P Gougis, S Magnifico, S Betuing, D Kilinc, JL Viovy and B Brugg, “Microfluidic chips with ‘axon diodes’ for directed axonal outgrowth and reconstruction of complex live neural networks,” MicroTAS 2008: Proceedings of the 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, pp. 1329-1331, Oct 12-16, 2008, San Diego, CA.
Kilinc D, "Mechanisms and prevention of axonal damage in response to mechanical trauma to cultured neurons," Ph.D. Thesis, Drexel University, Philadelphia, PA.
Kilinc D, G Gallo and KA Barbee. Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage. Exp Neurol 212:422-430.
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2007
Sasoglu FM, D Kilinc, K Allen and B Layton. "Towards a method for printing a network of chick forebrain neurons for biosensor applications," EMBC'07: Proceedings of the 29th IEEE EMBS Annual International Conference, pp. 4092-4095, Aug 23-26, 2007, Lyon, France.
Kilinc D, G Gallo and KA Barbee. "Poloxamer 188 reduces axonal beading following mechanical trauma to cultured neurons," EMBC'07: Proceedings of the 29th IEEE EMBS Annual International Conference, pp. 5395-5398, Aug 23-26, 2007, Lyon, France.
Sasoglu FM, D Kilinc, K Allen and B Layton. "Parallel force measurements in cell arrays," Proceedings of the ASME International Mechanical Engineering Congress and Exposition (IMECE), November 11-15, 2007, Seattle, WA.
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2005
Kilinc D, G Gallo and KA Barbee. “Effects of shear stress injury on the morphology and structure of cultured chick forebrain neurons,” BIYOMUT: Proceedings of the Biomedical Engineering National Meeting, pp. 191-196, May 25-26, 2005, Istanbul, Turkey.
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